The Reds will head to Germany - from where they have just returned from the Audi Cup - for the first leg on August 15 and welcome Julian Nagelsmann's side to Anfield the following week.
Klopp knows Hoffenheim well from his time in charge of Mainz and Borussia Dortmund and will not be taking the Bundesliga side lightly.
He told Liverpool's official website after the draw in Nyon: "Very interesting. Actually, it was exactly what I expected when I had a look – if there's a choice we always seem to take the German team. Sorry!
"It was clear from the first moment when we knew who we could face that there would be no easy game. It's Hoffenheim and that's for sure not an easy game.
"But we should always not forget what they thought in the moment they saw the draw – it's not the best thing they could get.
"I'm completely fine with it, happy to know and now we can start preparing. [They are a] strong side, how everybody can imagine. When you are fourth in Germany you are a strong side.
"It's a very interesting club. They have a lot of really good young players. They lost two of them – [Sebastian] Rudy and [Niklas] Sule to Bayern – and had a little change. [They have] a very young manager, just 30 years old, a very talented man.
"That's a real challenge but I’m looking forward to it. First we’ll play Watford but at the same time we'll start preparing for Hoffenheim and it's really exciting."
The match pits Roberto Firmino against his old club.