The 34-year-old striker was rewarded for his career-best season in front of goal at Tuesday night's Wanderers Medal in Sydney, where his teammates voted him for the club's highest honour.
Santalab is the Wanderers' top-scorer this campaign with 14 goals and has overtaken Mark Bridge's all-time club record, setting a new mark of 37 goals over his four seasons.
Defender Caitlin Cooper took home the women's top gong in her fourth W-League season for the Wanderers.
Argentine marquee playmaker Nicolas Martinez was another big winner, claiming the Rod Allen Award for media player of the year as well as members' player of the year, while Kearyn Baccus' younger brother Keanu was named best National Youth League player.
Wanderers Award Winners:
A-League player of the year: Brendon Santalab
W-League player of the year: Caitlin Cooper
Members' player of the year: Nicolas Martinez
Rod Allen Award: media player of the year: Nicolas Martinez
National Youth League player of the year: Keanu Baccus
Powerchair player of the year: Abdullah Karim
A-League golden boot: Brendon Santalab
W-League golden boot: Katie Stengel
Chairman's award: Bernie McLeod and Lawrence Gilbert
Wandercrew volunteer of the year: William Renton