Andrew Hoole of Newcastle Jets scored a hat-trick and Perth Glory's Jamie Maclaren bagged a double for the Olyroos before Myanmar grabbed a consolation.
Australia finished with three wins from three in Group F, scoring 15 goals in the process and conceeding just one.
Australia will be join the other nine group winners, five best second-placed teams and hosts Qatar at the AFC U-23 Championship 2016 with a top three finish ensuring a spot at the 2016 Olympic Games in Rio, Brazil.
Australia 5 Hoole 10', Maclaren 13', Maclaren 57', Hoole 68', Hoole 70'
Myanmar 1 Kaung Sat Naing 78'
Olyroos coach Aurelio Vidmar was pleased by the results but more impressed with the way the players bought in to the National Team blueprint laid down by Socceroos Coach Ange Postecoglou.
“The players were brilliant on and off the field and deserve the success they had,” Vidmar said. “We played some good football and controlled all three matches but the way they bought into what we are trying to achieve across all the National teams was outstanding.
“We created an identical structure and atmosphere to what has been successful for the Socceroos and the players and staff were thoroughly professional to ensure we won three games in five days under testing conditions.”