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Ryan's Club Brugge eclipses Besiktas
Just 13.21 seconds were on the clock when Vitolo struck, and Sevilla went on to beat Spanish rival Villarreal 3-1 at El Madrigal in the first leg of their last-16 clash.
Stephane Mbia doubled the visitor's lead in the 26th minute and, although Luciano Vietto pulled one back three minutes after half-time, two minutes later Kevin Gameiro added Sevilla's third.
Gonzalo Higuain was the main man for Napoli as his first European hat-trick guided the Italian side to a 3-1 victory over Dinamo Moscow.
Kevin Kuranyi gave the Russian side the lead in only the second minute but Higuain headed in his first after 25 minutes to level proceedings.
Six minutes later he put Napoli ahead from the penalty spot after a foul on Dries Mertens and Dinamo's night took another turn for the worse when Roman Zobnin was sent off on his European debut just after half-time.
In the 55th minute Higuain completed the scoring, and his hat-trick, with a well-struck volley.
Fiorentina and Roma will go into the second leg of their all-Italian clash level at 1-1.
Josip Ilicic gave Fiorentina the lead in the 17th minute, and goalkeeper Neto preserved it by pushing away Adem Ljajic's 60th-minute penalty.
But Roma was not to be denied and Seydou Keita's header 13 minutes from time gave it the all-important away goal.
Everton, the only English side left in the competition, ground out a 2-1 victory against Dynamo Kiev at Goodison Park.
Oleh Gusev put the visitor in front in the 14th minute but Steven Naismith levelled matters six minutes before half-time and Romelu Lukaku's 82nd-minute penalty won it for Everton.
Danilo Silva's handball allowed Lukaku to roll in the spot-kick, with his seventh goal making him Everton's record European goalscorer.
