The Wanderers take on no less than the A-League title favourite at Parramatta Stadium only two days after beating Melbourne City 3-2 in its third game in a week on Wednesday.
The players and staff with then pack their bags to travel to South Korea to face FC Seoul next Wednesday.
The relentless schedule has seen the Wanderers travel to Asia and across the country as they juggle both their A-League and AFC Champions League campaigns and it's taking a huge toll on Popovic's squad.
Having lost both Brendon Santalab (shoulder) and Shannon Cole (collarbone) to season-ending injuries, Popovic was then also left without Brendan Hamill (torn quadriceps) and Mark Bridge (groin) - the duo will be racing the clock to make it back before the end of the season.
Wednesday's come-from-behind victory, courtesy of a Nikita Rukavytsya winner at the death, was just the Wanderers' second of the season, finally lifting them off the bottom of the ladder.
But it proved costly with key midfielder Mateo Poljak suffering a calf injury.
Popovic retained just four players on Wednesday from the starting line-up that lost to Brisbane on Sunday as he rotates his squad to cope with the heavy load.
The coach had to dig so far into his reserves he gave 18 year-old Jonathan Aspropotamitis from the youth squad his debut against City as he admits "players are starting to fall apart".
Popovic, who played for years as defender at English club Crystal Palace, says he's never endured such a hectic schedule.
"I played in the Championship, which was a very tough, gruelling league and never did I play seven in 20 days," he said.
"We've had to endure travel, hot conditions in Adelaide and Brisbane, the Champions League. It's beyond belief in some respects.
"But you don't score late goals like we just did if you're feeling sorry for yourself.
"We're certainly not as fit as we want to be that's why we've got injuries, but there's a lot of fight."
Last time Western Sydney faced Victory a late Gui Finkler winner secured Melbourne the win.
Popovic says, busy schedule or not, this time he's confident the Wanderers can turn the tables.
"We won't have any excuses on Friday," he said.
"Victory will be a very tough game but my memory of the last time we played them we certainly matched them that day.
"They beat us with a bit of quality and took their chances, we didn't.
"Hopefully this time we'll put away our chances and I believe we can get the result."
