The AC Milan striker could lead the line for Cesare Prandelli's side when the nations meet in Manaus on 15 June (AEST) for their World Cup opener.
In what will be Balotelli's first outing at the tournament, he dismissed any chance of England winning the competition or posing a threat to Italy.
The former Manchester City man believes that Italy has more experience among its squad and the capability to spring a surprise in South America.
"I don't look at England as a team that can win the World Cup," The Daily Mail quotes him as saying.
"They have some good players, but they are no real rivals for Italy.
"I am not saying that Italy are favourites, but we have the mentality and experienced players to surprise people - I don't think England have that."
Four-time winner Italy will also contest Group D with Uruguay and Costa Rica as it seeks to overcome the disappointment of 2010 where it bowed out at the pool stage without a win.
With many of the current squad crowned world champions in Germany four years earlier, Balotelli feels their experience could give them an extra advantage against Roy Hodgson's men.
"We have players who have won the World Cup," he explained.
"I don't think England have a player who knows what it is like to play past the quarter-final."