Low's side was 3-0 victors against the same opposition on Friday, with the triumph seeing it go five points clear of second-placed Sweden, who has a game in hand.
Bastian Schweinsteiger, Mario Gotze and Thomas Muller were all on target in Astana, but the former will be suspended for Tuesday's game.
Despite the Bayern Munich midfielder's absence, Germany should prove too strong for a Kazakhstan side who has picked up just one point from its opening five matches.
"If you score a victory away then there is the danger that you keep this in your head for some time," Low told reporters. "We have to keep reminding the players that we are playing at home and we will only win if we have the right attitude."
Republic of Ireland can move into second if it gets past Austria at the Aviva Stadium - although it will be without record goalscorer Robbie Keane.
The Los Angeles Galaxy striker picked up a calf strain in Friday's goalless draw in Sweden and is set to be replaced by Wolves striker Kevin Doyle.
The Republic's home form has been far from ideal with a 6-1 reverse against Germany in October still fresh in their minds. However defender John O'Shea is confident it can register a vital three points.
"If we can start on the front foot, like we did against Sweden, and have the pressing, cohesive unit that we had the other night and stop Austria playing, then we can build our attacks from there," he said.
"But let's wait and see how they decide to approach the game as well.
"It will be on us as the home side, but we are not going to be too silly and go gung-ho because they have got lots of attacking threats.''
Austria is the group's second top scorers with 11 goals so far and is ahead of Giovanni Trapattoni's side courtesy of its far superior goal difference.
Thumping victories over Kazakhstan, and, on Friday against San Marino, has certainly helped Marcel Koller's side, who is wary of the Irish threat.
"Ireland are a different standard than the Faroe Islands. Every player must be aware that it will be harder," he told reporters.
"We were a little bit too loose at times and did not keep our organisation as I would have liked. And if we slack off against strong teams like the Irish, they will strike. If they see an opportunity, they will bite.
"We will pick a team so that we can win. We want to win. But if a draw looks likely, we will take a point."